Schedule:
8:45 - 9:00am Introduction (featuring remarks from Kate Barlett, MDSC Self-Advocate Advisory Council)
Session 1: Developmental biology
9:00 - 9:40am Elizabeth Fisher (keynote), University College London : Working with mouse models to understand Down syndrome
9:40 - 10:05am Laurie Boyer, MIT, Getting to the Heart of Down Syndrome
10:05 -10:30am Tarik Haydar, Center for Neuroscience Research, Children’s National Hospital, Variation in phenotypic presentation of mouse models of Down syndrome, findings and implications
10:30 -10:55am Lindy Barrett, Broad Institute, MIT and Harvard, Probing molecular convergence between Down syndrome and Fragile X syndrome
10:55 - 11:10am Break
Session 2: Alzheimer’s Disease in Down Syndrome – Recent Advances
11:10 -11:35am Diana Rosas, Massachusetts General Hospital Neurology
11:35am - 12:00pm Stephanie Santoro Massachusetts General Hospital Down Syndrome Program, LIFE-DSR study and assessment scales for AD in DS
12:00 -12:25pm Li-Huei Tsai and Diane Chan, Alana Down Syndrome Center at MIT, Leveraging Brain Rhythms As A Therapeutic Intervention For Alzheimer’s Disease
12:25 - 12:45pm Tribute to Angelika Amon (featuring remarks from Li-Huei Tsai, Claudia Moreira, Manolis Kellis, Laurie Boyer, Brian Skotko, Ed Boyden, and Emily Niederst)
12:45 - 1:30pm Lunch
Session 3: Dosage compensation/aneuploidy
1:30 -2:10pm Jeannie Lee (keynote), Harvard Medical School, Manipulating X-chromosome dosage to treat human disorders
2:10 - 2:35pm Stefan Pinter , University of Connecticut, Trisomy 21 silencing: Towards a dynamic in vitro model of Down Syndrome
2:35 - 3:00pm Mitzi Kuroda, Harvard Medical School , X chromosome dosage compensation in Drosophila
3:00 - 3:15pm Break
Session 4: Sleep Apnea in Down Syndrome
3:15 - 3:40pm Daniel Combs, University of Arizona, Medications for Obstructive Sleep Apnea in Children with Down Syndrome
3:40 - 4:05pm Christopher Hartnick, Harvard Medical School, HGN Implant for Severe Sleep Apnea: Where are we now?
4:05 pm Closing Remarks and Angelika Amon Tribute Video